Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 15/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 14/20 | 0.43 |
| ▸ | PPARD | Q03181 | 11/20 | 0.43 |
| ▸ | PPARA | Q07869 | 10/20 | 0.43 |
| ▸ | PPARG | P37231 | 10/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5953435 | 0.87 | NR1H3 (0.58) | NR1H3NR1H2PPARDPPARAPPARG | |
| SCHEMBL5576817 | 0.78 | NR1H3 (0.48) | NR1H3NR1H2PPARDPPARAPPARG | |
| SCHEMBL6165165 | 0.77 | NR1H3 (0.52) | NR1H3NR1H2PPARDPPARAPPARG | |
| SCHEMBL6167606 | 0.75 | NR1H3 (0.40) | NR1H3NR1H2PPARDPPARAPPARG | |
| SCHEMBL6167330 | 0.74 | NR1H3 (0.50) | NR1H3NR1H2PPARDPPARAPPARG | |
| SCHEMBL6168914 | 0.72 | NR1H3 (0.45) | NR1H3NR1H2PPARDPPARAPPARG | |
| SCHEMBL6167313 | 0.72 | NR1H3 (0.47) | NR1H3NR1H2PPARDPPARAPPARG | |
| SCHEMBL6367243 | 0.72 | NR1H2 (0.54) | NR1H3NR1H2PPARDPPARAPPARG | |
| SCHEMBL5319506 | 0.71 | NR1H3 (0.61) | NR1H3NR1H2PPARDPPARAPPARG | |
| SCHEMBL5319347 | 0.71 | NR1H3 (0.59) | NR1H3NR1H2PPARDPPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758651-A2 | LXR AGONISTS TO PROMOTE BONE HOMEOSTASIS | Galapagos N.V. (BE) | 2007-03-07 | — | — | EP | disclosed |
| WO-2006000577-A9 | LXR AGONISTS TO PROMOTE BONE HOMEOSTASIS | GALAPAGOS GENOMICS NV (BE) | 2006-04-20 | — | — | WO | disclosed |
| WO-2006000577-A2 | LXR AGONISTS TO PROMOTE BONE HOMEOSTASIS | GALAPAGOS N.V. (BE) | 2006-01-05 | — | — | WO | disclosed |