Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | CLK3 | P49761 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5629675 | 1.00 | DYRK3 (0.34) | DYRK3CLK1CLK2CLK3DYRK1A | |
| SCHEMBL5573823 | 0.90 | ELANE (0.40) | ALDH1A1TRPM5MEN1KMT2AELANE | |
| SCHEMBL5573825 | 0.90 | ELANE (0.40) | ALDH1A1TRPM5MEN1KMT2AELANE | |
| SCHEMBL5570175 | 0.89 | PDE10A (0.34) | CLK4NPC1RAB9AGAAMAPT | |
| SCHEMBL5573751 | 0.86 | APP (0.36) | CLK4ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL5573752 | 0.86 | APP (0.36) | CLK4ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL5573841 | 0.83 | ALDH1A1 (0.36) | DYRK3ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL5571296 | 0.83 | ALDH1A1 (0.36) | DYRK3ALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL5573275 | 0.83 | PIK3CA (0.38) | — | |
| SCHEMBL5573277 | 0.83 | PIK3CA (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084673-A1 | 1,5-naphthyridine azolinone | LIU JIN-JUN | 2006-04-20 | — | — | US | claimed |
| US-7268231-B2 | 1,5-Naphthyridine azolinone | HOFFMANN-LA ROCHE INC. (US) | 2007-09-11 | — | — | US | disclosed |
| EP-1805174-A1 | 1,5-NAPHTHYRIDINE AZOLIDINONES HAVING CDK1 ANTIPROLIFERATIVE ACTIVITY | F.HOFFMANN-LA ROCHE AG (CH) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006040052-A1 | 1,5-NAPHTHYRIDINE AZOLIDINONES HAVING CDK1 ANTIPROLIFERATIVE ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2006-04-20 | — | — | WO | disclosed |
| US-20060084673-A1 | 1,5-naphthyridine azolinone | LIU JIN-JUN | 2006-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084673-A1 | 1,5-naphthyridine azolinone | CDK1, CDK15, CDK14 | DYRK3 1522/4885CLK1 907/4885CLK2 710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.