Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | TACR1 | P25103 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4465349 | 1.00 | MEN1 (0.45) | MEN1KMT2APDE4BRORCTACR1 | |
| SCHEMBL4465346 | 1.00 | MEN1 (0.45) | MEN1KMT2APDE4BRORCTACR1 | |
| SCHEMBL13077736 | 0.80 | PDE4B (0.48) | PDE4BRORCTACR1KDM4ENAMPT | |
| SCHEMBL16780715 | 0.80 | PDE4B (0.48) | MEN1KMT2APDE4BRORCTACR1 | |
| SCHEMBL16780718 | 0.80 | PDE4B (0.48) | MEN1KMT2APDE4BRORCTACR1 | |
| SCHEMBL3744409 | 0.80 | PDE4B (0.48) | PDE4BRORCTACR1KDM4ENAMPT | |
| SCHEMBL16780215 | 0.80 | RORC (0.51) | MEN1KMT2APDE4BRORCTACR1 | |
| SCHEMBL16780714 | 0.80 | PDE4B (0.48) | MEN1KMT2APDE4BRORCTACR1 | |
| SCHEMBL13858400 | 0.80 | RORC (0.51) | MEN1KMT2APDE4BRORCTACR1 | |
| SCHEMBL31450144 | 0.80 | PDE4B (0.48) | MEN1KMT2APDE4BRORCTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778225-A2 | PYRROLO(OXO)ISOQUINOLINES AS 5HT LIGANDS | Bristol-Myers Squibb Company (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006019886-A2 | PYRROLO(OXO)ISOQUINOLINES AS 5HT LIGANDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-02-23 | — | — | WO | disclosed |