Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | VCP | P55072 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3251691 | 1.00 | AURKA (0.36) | AURKAGAATP53POLBMAPT | |
| SCHEMBL3248475 | 0.81 | KDM4E (0.33) | GRM5 | |
| SCHEMBL3254180 | 0.79 | MERTK (0.34) | — | |
| SCHEMBL3254181 | 0.79 | MERTK (0.34) | — | |
| SCHEMBL3254176 | 0.79 | MERTK (0.34) | — | |
| SCHEMBL3251095 | 0.75 | AURKA (0.45) | AURKAGAATP53POLBMAPT | |
| SCHEMBL3254024 | 0.72 | PLAU (0.34) | GRM5 | |
| SCHEMBL3248012 | 0.72 | ADK (0.42) | GAAMAPT | |
| SCHEMBL3264002 | 0.71 | ADK (0.39) | MAPT | |
| SCHEMBL3251683 | 0.71 | ACACB (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205297-B2 | Substituted 5-alkynyl pyrimidines having neurotrophic activity | KRENITSKY PHARMACEUTICALS, INC. (US) | 2007-04-17 | — | — | US | disclosed |