SCHEMBL5575437

SCHEMBL5575437

COC(=O)c1cc(SCc2cc(SCc3ccc(SC(=O)N(C)C)cc3)cc(SCc3ccc(SC(=O)N(C)C)cc3)c2)cc(SCc2cc(SCc3ccc(SC(=O)N(C)C)cc3)cc(SCc3ccc(SC(=O)N(C)C)cc3)c2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.43
TP53 P04637 1/20 0.43
NPC1 O15118 7/20 0.42
RAB9A P51151 5/20 0.42
SMN1; SMN2 Q16637 5/20 0.42
ALDH1A1 P00352 5/20 0.42
MAPT P10636 4/20 0.42
LMNA P02545 2/20 0.42
HPGD P15428 3/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
KMT2A Q03164 3/20 0.37
MAPK1 P28482 3/20 0.37
MEN1 O00255 2/20 0.37
TSHR P16473 2/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
NPSR1 Q6W5P4 1/20 0.36
GSK3A P49840 2/20 0.36
GSK3B P49841 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5574874 1.00 CYP1A2 (0.43) CYP1A2TP53NPC1RAB9ASMN1; SMN2
SCHEMBL5574878 0.97 CYP1A2 (0.45) CYP1A2TP53NPC1RAB9ASMN1; SMN2
SCHEMBL14511530 0.91 CYP1A2 (0.40) CYP1A2TP53NPC1RAB9ASMN1; SMN2
SCHEMBL6032571 0.86 ALDH1A1 (0.39) NPC1RAB9ASMN1; SMN2ALDH1A1MAPT
SCHEMBL5574327 0.83 ALDH1A1 (0.41) CYP1A2NPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL5574926 0.83 ALDH1A1 (0.41) CYP1A2NPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL5571099 0.82 ALDH1A1 (0.40) NPC1RAB9ASMN1; SMN2ALDH1A1MAPT
SCHEMBL6031741 0.82 ALDH1A1 (0.40) CYP1A2NPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL5574233 0.82 ALDH1A1 (0.42) CYP1A2NPC1RAB9ASMN1; SMN2ALDH1A1
SCHEMBL5575486 0.81 ALDH1A1 (0.41) NPC1RAB9ASMN1; SMN2ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070172600-A1 Molecular bonding method and molecular bonding device NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATION TECHNOLOGY INCORPORATED (JP) 2007-07-26 US disclosed
US-20070172600-A1 Molecular bonding method and molecular bonding device NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATION TECHNOLOGY INCORPORATED (JP) 2007-07-26 US disclosed
US-20070114400-A1 Probe NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY, INCORPORATED (JP) 2007-05-24 US disclosed
US-20070114400-A1 Probe NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY, INCORPORATED (JP) 2007-05-24 US disclosed
EP-1623953-A1 PROBE National Institute of Information and Communications Technology (JP) 2006-02-08 EP disclosed
EP-1621517-A1 METHOD OF BONDING MOLECULE AND MOLECULE BONDING APPARATUS National Institute of Information and Communications Technology (JP) 2006-02-01 EP disclosed