Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.55 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.54 |
| ▸ | TUBB | P07437 | 1/20 | 0.54 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.54 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.54 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.54 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.54 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.54 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.54 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.54 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14454077 | 1.00 | TNFRSF1A (1.00) | TNFRSF1AMAPTALDH1A1LMNAKDM4E | |
| SCHEMBL14454078 | 0.88 | TNFRSF1A (1.00) | TNFRSF1AMAPTALDH1A1LMNAKDM4E | |
| SCHEMBL5960638 | 0.77 | TNFRSF1A (1.00) | TNFRSF1AALDH1A1SMN1; SMN2CYP1A1CYP1A2 | |
| SCHEMBL5960636 | 0.77 | TNFRSF1A (1.00) | TNFRSF1AALDH1A1SMN1; SMN2CYP1A1CYP1A2 | |
| SCHEMBL5576293 | 0.77 | TNFRSF1A (0.65) | TNFRSF1AMAPTALDH1A1LMNAKDM4E | |
| SCHEMBL7730270 | 0.76 | KDM4E (0.79) | TNFRSF1AALDH1A1KDM4ESMN1; SMN2TUBB4A | |
| SCHEMBL1134588 | 0.76 | KDM4E (0.79) | TNFRSF1AALDH1A1KDM4ESMN1; SMN2TUBB4A | |
| SCHEMBL28914840 | 0.76 | GAA (0.79) | TNFRSF1AALDH1A1KDM4ETUBB4ATUBB | |
| SCHEMBL30122806 | 0.76 | GAA (0.79) | TNFRSF1AALDH1A1KDM4ETUBB4ATUBB | |
| SCHEMBL11469836 | 0.75 | TNFRSF1A (0.60) | TNFRSF1AMAPTALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7247714-B2 | Protection against oxidative stress and inflammation by a cytoprotective response element | ATHEROGENICS, INC. (US) | 2007-07-24 | — | — | US | disclosed |