Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 20/20 | 0.71 |
| ▸ | INSR | P06213 | 11/20 | 0.68 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.66 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.66 |
| ▸ | PRKCG | P05129 | 1/20 | 0.66 |
| ▸ | LCK | P06239 | 1/20 | 0.66 |
| ▸ | KIT | P10721 | 1/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.66 |
| ▸ | SRC | P12931 | 1/20 | 0.66 |
| ▸ | FLT1 | P17948 | 1/20 | 0.66 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.66 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.66 |
| ▸ | KDR | P35968 | 1/20 | 0.66 |
| ▸ | FLT3 | P36888 | 1/20 | 0.66 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.66 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.66 |
| ▸ | PLK1 | P53350 | 1/20 | 0.66 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.66 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5576415 | 0.89 | ITK (0.69) | ITKINSRCHEK2NTRK1PRKCG | |
| SCHEMBL6261946 | 0.85 | ITK (0.53) | ITKINSRCHEK2NTRK1PRKCG | |
| SCHEMBL14698937 | 0.79 | ITK (0.84) | ITKINSRCHEK2NTRK1PRKCG | |
| SCHEMBL6416912 | 0.79 | ITK (0.72) | ITKINSR | |
| SCHEMBL14586355 | 0.79 | ITK (1.00) | ITKINSR | |
| SCHEMBL5576408 | 0.78 | ITK (0.48) | ITKINSRCHEK2NTRK1PRKCG | |
| SCHEMBL14699309 | 0.78 | ITK (0.72) | ITKINSRCHEK2NTRK1PRKCG | |
| SCHEMBL14698857 | 0.78 | ITK (0.83) | ITKINSRCHEK2NTRK1PRKCG | |
| SCHEMBL14698895 | 0.77 | ITK (0.78) | ITKINSRCHEK2NTRK1PRKCG | |
| SCHEMBL14698272 | 0.76 | ITK (0.70) | ITKINSRCHEK2NTRK1PRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070032403-A1 | Crystal structure of the ITK kinase domain | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2007-02-08 | — | — | US | disclosed |
| WO-2005066335-A1 | CRYSTAL STRUCTURE OF THE INTERLEUKIN-2-INDUCIBLE CELL KINASE (ITK) KINASE DOMAIN | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032403-A1 | Crystal structure of the ITK kinase domain | ITK, DTYMK, WEE1 | ITK 1/4885INSR 299/4885CHEK2 148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.