SCHEMBL5576882

SCHEMBL5576882

CCOC(=O)[C@@H](N)Cc1ccc(NC(=O)c2c(Cl)cncc2Cl)cn1

nearest known ligand 0.45

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ITGB1 P05556 20/20 0.45
ITGA4 P13612 20/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13913377 0.86 ITGB1 (0.58) ITGB1ITGA4
SCHEMBL13932614 0.86 ITGB1 (0.58) ITGB1ITGA4
SCHEMBL5261605 0.86 ITGB1 (0.58) ITGB1ITGA4
SCHEMBL2979007 0.85 ITGB1 (0.55) ITGB1ITGA4
Hydrochloric Acid SCHEMBL5985422 0.85 ITGB1 (0.57) ITGB1ITGA4
Hydrochloric Acid SCHEMBL4306932 0.85 ITGB1 (0.57) ITGB1ITGA4
SCHEMBL5149425 0.81 ITGB1 (0.44) ITGB1ITGA4
SCHEMBL3830533 0.79 ITGB1 (0.43) ITGB1ITGA4
SCHEMBL5576889 0.77 ITGB1 (0.56) ITGB1ITGA4
SCHEMBL3834956 0.77 ITGB1 (0.42) ITGB1ITGA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1780201-A2 PHENYLALANINE ENAMIDE DERIVATIVES POSSESSING A CYCLOBUTENE GROUP, FOR USE AS INTEGRIN INHIBITORS Celltech R&D Limited (GB) 2007-05-02 EP disclosed