SCHEMBL5576889

SCHEMBL5576889

CCN[C@@H](Cc1ccc(NC(=O)c2c(Cl)cncc2Cl)cn1)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ITGB1 P05556 20/20 0.56
ITGA4 P13612 20/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5149608 0.84 ITGB1 (0.75) ITGB1ITGA4
SCHEMBL2979007 0.82 ITGB1 (0.55) ITGB1ITGA4
SCHEMBL2974007 0.82 ITGB1 (0.56) ITGB1ITGA4
SCHEMBL5670178 0.80 ITGB1 (0.52) ITGB1ITGA4
SCHEMBL2987190 0.80 ITGB1 (0.52) ITGB1ITGA4
SCHEMBL2982228 0.79 ITGB1 (0.51) ITGB1ITGA4
SCHEMBL2976339 0.79 ITGB1 (0.52) ITGB1ITGA4
Hydrochloric Acid SCHEMBL2982337 0.78 ITGB1 (0.50) ITGB1ITGA4
SCHEMBL5576882 0.77 ITGB1 (0.45) ITGB1ITGA4
SCHEMBL2982476 0.76 ITGB1 (0.50) ITGB1ITGA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1780201-A2 PHENYLALANINE ENAMIDE DERIVATIVES POSSESSING A CYCLOBUTENE GROUP, FOR USE AS INTEGRIN INHIBITORS Celltech R&D Limited (GB) 2007-05-02 EP disclosed