Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5577940 | 0.82 | ALDH1A1 (0.37) | SCN9AKDM4EALDH1A1KMT2AHSD17B10 | |
| SCHEMBL5577963 | 0.80 | GPBAR1 (0.35) | SCN9AKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL5578052 | 0.69 | — | — | |
| SCHEMBL5577959 | 0.68 | JAK2 (0.35) | SCN9AALDH1A1KMT2AHSD17B10 | |
| SCHEMBL3501106 | 0.66 | POLB (0.36) | KDM4EALDH1A1KMT2AHSD17B10MEN1 | |
| SCHEMBL4753920 | 0.65 | GRIN1 (0.39) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL5578043 | 0.61 | — | — | |
| SCHEMBL4020818 | 0.59 | MAPK14 (0.38) | SCN9AALDH1A1KMT2AHSD17B10 | |
| SCHEMBL4013981 | 0.58 | HSP90AA1 (0.41) | SCN9AKDM4EALDH1A1KMT2AHSD17B10 | |
| SCHEMBL12543097 | 0.57 | KMT2A (0.55) | KDM4EALDH1A1KMT2AHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070173488-A1 | Pyrazolothiazole Protein Kinase Modulators | SGX PHARMACEUTICALS, INC. (US) | 2007-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173488-A1 | Pyrazolothiazole Protein Kinase Modulators | MAP4K2, MAP4K5, MAP4K3 | SCN9A 3587/4885KDM4E 1377/4885ALDH1A1 3700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.