Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5577969 | 0.88 | PRKAB2 (0.35) | CYP1A2CYP2C9CYP2C19GRIN1GRIN2B | |
| Hydrochloric Acid SCHEMBL5577972 | 0.84 | CYP2C19 (0.30) | CYP2C19 | |
| SCHEMBL5578030 | 0.78 | HPGD (0.39) | HPGDCYP1A2CYP2C9CYP2C19GRIN1 | |
| SCHEMBL5578039 | 0.77 | HPGD (0.40) | HPGDCYP1A2CYP2C9CYP2C19GRIN1 | |
| SCHEMBL5577963 | 0.76 | GPBAR1 (0.35) | ALDH1A1KDM4E | |
| SCHEMBL14454974 | 0.73 | HPGD (0.38) | HPGDCYP1A2CYP2C9CYP2C19GRIN1 | |
| SCHEMBL5577964 | 0.66 | PRKAB2 (0.36) | CYP1A2CYP2C9CYP2C19GRIN1GRIN2B | |
| SCHEMBL5577974 | 0.66 | PRKAB2 (0.38) | CYP1A2CYP2C9CYP2C19TSHRCYP3A4 | |
| SCHEMBL14454975 | 0.64 | ADORA2A (0.37) | HPGDALDH1A1KDM4EROCK2 | |
| SCHEMBL14454979 | 0.64 | MCHR1 (0.35) | HPGDALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070173488-A1 | Pyrazolothiazole Protein Kinase Modulators | SGX PHARMACEUTICALS, INC. (US) | 2007-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173488-A1 | Pyrazolothiazole Protein Kinase Modulators | MAP4K2, MAP4K5, MAP4K3 | HPGD 1949/4885CYP1A2 3327/4885CYP2C9 3910/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.