Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 3/20 | 0.33 |
| ▸ | ACACB | O00763 | 4/20 | 0.32 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3901448 | 0.81 | APP (0.42) | CYP1A2CYP2C19L3MBTL1APP | |
| SCHEMBL26259756 | 0.78 | ACACB (0.35) | CYP1A2TDP1L3MBTL1ACACB | |
| SCHEMBL19432861 | 0.77 | FFAR1 (0.36) | TDP1FFAR1GRM5HSD17B2APP | |
| SCHEMBL26259881 | 0.76 | ACACB (0.34) | CYP1A2TDP1L3MBTL1ACACB | |
| SCHEMBL4269320 | 0.73 | ACACB (0.37) | ACACB | |
| SCHEMBL26259731 | 0.73 | ACACB (0.43) | CYP1A2CYP2C19TDP1L3MBTL1ACACB | |
| SCHEMBL13394634 | 0.71 | GRM5 (0.39) | FFAR1GRM5HSD17B2APP | |
| SCHEMBL8375667 | 0.71 | NQO1 (0.58) | CYP1A2CYP2D6CYP2C19TDP1L3MBTL1 | |
| SCHEMBL27138663 | 0.71 | MAPT (0.33) | CYP1A2CYP2C19GRM5MEN1KMT2A | |
| SCHEMBL21183960 | 0.70 | MAOA (0.39) | FFAR1GRM5HSD17B2APPAOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070105900-A1 | Pharmaceutical compounds | ATEX THERAPEUTICS, LIMITED (GB) | 2007-05-10 | — | — | US | disclosed |
| EP-1648449-A2 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASES INHIBITORS | Astex Therapeutics Limited (GB) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005002576-A2 | IMIDAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASES INHIBITORS | ASTEX THERAPEUTICS LIMITED (GB) | 2005-01-13 | — | — | WO | disclosed |
| EP-0006452-B1 | HYPOGLYCEMIC PHENYLPROPYNYLAMINO BENZOIC ACIDS, THEIR SALTS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS AND THEIR APPLICATION | THE DOW CHEMICAL COMPANY (US) | 1983-02-16 | — | — | EP | disclosed |
| US-4263320-A | ANTIDIABETIC AGENTS | THE DOW CHEMICAL COMPANY (US) | 1981-04-21 | — | — | US | disclosed |
| EP-0006452-A1 | Hypoglycemic phenylpropynylamino benzoic acids, their salts, pharmaceutical compositions containing said compounds and their application | THE DOW CHEMICAL COMPANY (US) | 1980-01-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105900-A1 | Pharmaceutical compounds | AURKA, AURKC, CDK1 | CYP1A2 1378/4885CYP2D6 1906/4885CYP2C19 1774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.