Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 11/20 | 0.58 |
| ▸ | FADS1 | O60427 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5578380 | 0.83 | PDE10A (0.53) | PDE10AMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL5578698 | 0.82 | MEN1 (0.52) | PDE10AMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL15154005 | 0.79 | PDE10A (0.77) | PDE10AMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL27592014 | 0.79 | PDE10A (0.57) | PDE10AMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL15164727 | 0.76 | PDE10A (0.69) | PDE10AMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL12659747 | 0.76 | HRH3 (0.54) | PDE10AMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL18076614 | 0.76 | PDE10A (0.60) | PDE10AMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL7147056 | 0.75 | PDE10A (0.60) | PDE10AMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL410424 | 0.74 | PDE10A (1.00) | PDE10AMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL5578377 | 0.74 | KCNH2 (0.49) | KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771447-A1 | FUSED PYRIMIDINE DERIVATIVES AND COMPOSITIONS THEREOF AS CXCR3 RECEPTOR MODULATORS, USEFUL IN PREVENTION AND TREATMENT OF INFLAMMATORY AND IMMUNOREGULATORY DISORDERS AND DISEASES | Amgen SF LLC (US) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006004915-A1 | FUSED PYRIMIDINE DERIVATIVES AND COMPOSITIONS THEREOF AS CXCR3 RECEPTOR MODULATORS, USEFUL IN PREVENTION AND TREATMENT OF INFLAMMATORY AND IMMUNOREGULATORY DISORDERS AND DISEASES | AMGEN SF, LLC (US) | 2006-01-12 | — | — | WO | disclosed |