Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 11/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5579057 | 0.91 | HDAC1 (0.48) | HDAC1HDAC6HDAC8FAAHOPRM1 | |
| SCHEMBL5578870 | 0.83 | HCRTR1 (0.43) | HDAC1HDAC6HDAC8FAAHOPRM1 | |
| SCHEMBL5578601 | 0.82 | AVPR1A (0.43) | HDAC1HDAC6HDAC8FAAHOPRM1 | |
| SCHEMBL5578589 | 0.78 | HDAC1 (0.46) | HDAC1HDAC6HDAC8TACR1 | |
| SCHEMBL5578491 | 0.76 | GLRA3 (0.41) | HDAC1HDAC6OPRM1OPRL1SMN1; SMN2 | |
| SCHEMBL5578553 | 0.76 | HDAC1 (0.49) | HDAC1HDAC6HDAC8OPRM1TACR1 | |
| SCHEMBL5578859 | 0.75 | HDAC1 (0.46) | HDAC1HDAC6HDAC8ALDH1A1TACR1 | |
| SCHEMBL5578577 | 0.72 | SMN1; SMN2 (0.48) | FAAHOPRM1OPRL1SMN1; SMN2HCRTR1 | |
| SCHEMBL5578503 | 0.68 | HDAC1 (0.50) | HDAC1HDAC6HDAC8NPSR1TACR1 | |
| SCHEMBL5578558 | 0.68 | TACR1 (0.39) | HDAC1HDAC6HDAC8TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070254903-A1 | Novel Spiroindoline or Spiroisoquinoline Compounds, Methods of Use and Compositions Thereof | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-01 | — | — | US | disclosed |
| US-20070254903-A1 | Novel Spiroindoline or Spiroisoquinoline Compounds, Methods of Use and Compositions Thereof | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-01 | — | — | US | disclosed |
| US-20070254903-A1 | Novel Spiroindoline or Spiroisoquinoline Compounds, Methods of Use and Compositions Thereof | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254903-A1 | Novel Spiroindoline or Spiroisoquinoline Compounds, Methods of Use and Compositions Thereof | REN, AVPR2, RECQL | HDAC1 885/4885HDAC6 767/4885HDAC8 2130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.