Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.39 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanine SCHEMBL2636587 | 0.92 | PNP (0.51) | PNPKDM4EMEN1ALDH1A1MAPT | |
| Guanine SCHEMBL2499473 | 0.92 | PNP (0.72) | PNPKDM4EMEN1ALDH1A1MAPT | |
| Guanine SCHEMBL79001 | 0.92 | PNP (0.72) | PNPKDM4EMEN1ALDH1A1MAPT | |
| Guanine SCHEMBL2528337 | 0.92 | PNP (0.72) | PNPKDM4EMEN1ALDH1A1MAPT | |
| Guanine SCHEMBL2529420 | 0.92 | PNP (0.72) | PNPKDM4EMEN1ALDH1A1MAPT | |
| Guanine SCHEMBL23576542 | 0.86 | PNP (0.63) | PNPKDM4EMEN1ALDH1A1MAPT | |
| Guanine SCHEMBL19991865 | 0.85 | PNP (0.62) | PNPKDM4EMEN1ALDH1A1MAPT | |
| Guanine SCHEMBL15718981 | 0.85 | PNP (0.43) | PNPKDM4EMEN1ALDH1A1MAPT | |
| Guanine SCHEMBL20518478 | 0.84 | PNP (0.55) | PNPKDM4EMEN1ALDH1A1MAPT | |
| Guanine SCHEMBL23880590 | 0.84 | PNP (0.55) | PNPKDM4EMEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2500437-B1 | Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same | PTC THERAPEUTICS INC (US) | 2016-11-30 | — | — | EP | disclosed |
| US-9493845-B2 | Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same | PTC THERAPEUTICS, INC. (US) | 2016-11-15 | — | — | US | disclosed |
| US-8618077-B2 | Compositions and methods for treating fragile X premutation RVGG repeats-mediated toxicity | EMORY UNIVERSITY (US) | 2013-12-31 | — | — | US | disclosed |
| US-20130347133-A1 | Methods For Identifying Compounds That Modulate Untranslated Region-Dependent Gene Expression And Methods Of Using Same | PTC THERAPEUTICS, INC. (US) | 2013-12-26 | — | — | US | disclosed |
| US-8460864-B2 | Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same | PTC THERAPEUTICS, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20120277178-A1 | COMPOSITIONS AND METHODS FOR TREATING FRAGILE X PREMUTATION RVGG REPEATS-MEDIATED TOXICITY | EMORY UNIVERSITY (US) | 2012-11-01 | — | — | US | disclosed |
| EP-2500437-A2 | Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same | PTC Therapeutics, Inc. (US) | 2012-09-19 | — | — | EP | disclosed |
| US-20070111203-A1 | Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same | PTC THERAPEUTICS | 2007-05-17 | — | — | US | disclosed |