Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 2/20 | 0.51 |
| ▸ | PI4KA | P42356 | 4/20 | 0.43 |
| ▸ | PI4K2B | Q8TCG2 | 4/20 | 0.43 |
| ▸ | PI4K2A | Q9BTU6 | 4/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanine SCHEMBL37966 | 0.93 | PNP (0.59) | PNPPI4KAPI4K2BPI4K2API4KB | |
| Guanine SCHEMBL4577523 | 0.93 | PNP (0.59) | PNPPI4KAPI4K2BPI4K2API4KB | |
| Guanine SCHEMBL15718981 | 0.92 | PNP (0.43) | PNPPI4KAPI4K2BPI4K2API4KB | |
| Guanine SCHEMBL5579240 | 0.92 | PNP (0.60) | PNPKDM4EMEN1ALDH1A1MAPT | |
| Guanine SCHEMBL9468227 | 0.91 | PNP (0.43) | PNPPI4KAPI4K2BPI4K2API4KB | |
| 2,6-Diaminopurine SCHEMBL23292805 | 0.88 | PNP (0.53) | PNPPI4KAPI4K2BPI4K2API4KB | |
| Guanine SCHEMBL5097009 | 0.87 | PNP (0.47) | PNPPI4KAPI4K2BPI4K2API4KB | |
| Guanine SCHEMBL9468295 | 0.86 | PNP (0.46) | PNPPI4KAPI4K2BPI4K2API4KB | |
| Guanine SCHEMBL17542296 | 0.85 | PNP (0.49) | PNPPI4KAPI4K2BPI4K2API4KB | |
| Adenine SCHEMBL6227732 | 0.85 | PI4KA (0.41) | PNPPI4KAPI4K2BPI4K2API4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458474-A1 | COMBINATIONS OF MRNAS ENCODING IMMUNE MODULATING POLYPEPTIDES AND USES THEREOF | Modernatx, Inc. (US) | 2019-03-27 | — | — | EP | disclosed |
| EP-3458092-A1 | MRNA COMBINATION THERAPY FOR THE TREATMENT OF CANCER | Modernatx, Inc. (US) | 2019-03-27 | — | — | EP | disclosed |
| EP-3458083-A1 | POLYNUCLEOTIDES ENCODING INTERLEUKIN-12 (IL12) AND USES THEREOF | Modernatx, Inc. (US) | 2019-03-27 | — | — | EP | disclosed |
| EP-3394093-A1 | METHODS OF USING OX40 LIGAND ENCODING POLYNUCLEOTIDES | Modernatx, Inc. (US) | 2018-10-31 | — | — | EP | disclosed |
| WO-2017201352-A1 | MRNA COMBINATION THERAPY FOR THE TREATMENT OF CANCER | MODERNATX, INC. (US) | 2017-11-23 | — | — | WO | disclosed |
| WO-2017201325-A1 | COMBINATIONS OF MRNAS ENCODING IMMUNE MODULATING POLYPEPTIDES AND USES THEREOF | MODERNATX, INC. (US) | 2017-11-23 | — | — | WO | disclosed |
| WO-2017201350-A1 | POLYNUCLEOTIDES ENCODING INTERLEUKIN-12 (IL12) AND USES THEREOF | MODERNATX, INC. (US) | 2017-11-23 | — | — | WO | disclosed |
| WO-2017112943-A1 | METHODS OF USING OX40 LIGAND ENCODING POLYNUCLEOTIDES | MODERNATX, INC. (US) | 2017-06-29 | — | — | WO | disclosed |
| EP-3157573-A2 | ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF | Moderna Therapeutics, Inc. (US) | 2017-04-26 | — | — | EP | disclosed |
| EP-3157572-A2 | ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF | Moderna Therapeutics, Inc. (US) | 2017-04-26 | — | — | EP | disclosed |
| WO-2015196128-A2 | ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF | MODERNA THERAPEUTICS, INC. (US) | 2015-12-23 | — | — | WO | disclosed |
| WO-2015196130-A2 | ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF | MODERNA THERAPEUTICS, INC. (US) | 2015-12-23 | — | — | WO | disclosed |
| WO-2014078652-A1 | HEAVY ATOM LABELED NUCLEOSIDES, NUCLEOTIDES, AND NUCLEIC ACID POLYMERS, AND USES THEREOF | ZS GENETICS, INC. (US) | 2014-05-22 | — | — | WO | disclosed |
| WO-2012075114-A2 | NUCLEIC ACID-POLYMER CONJUGATES AND USES THEREOF | ABLITECH, INC. (US) | 2012-06-07 | — | — | WO | disclosed |
| EP-2437789-A1 | BIOMOLECULE-POLYMER CONJUGATES AND METHODS OF MAKING SAME | Ablitech, Inc. (US) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010141507-A1 | BIOMOLECULE-POLYMER CONJUGATES AND METHODS OF MAKING SAME | ABLITECH, INC. (US) | 2010-12-09 | — | — | WO | disclosed |