Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 7/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | FER | P16591 | 1/20 | 0.48 |
| ▸ | LTK | P29376 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 2/20 | 0.43 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5579365 | 1.00 | TNKS2 (0.59) | TNKS2PDGFRAFERLTKCDK8 | |
| SCHEMBL2361451 | 0.82 | KDM4E (0.57) | TNKS2MAPTGAAALDH1A1KDM4E | |
| SCHEMBL12749304 | 0.76 | PBRM1 (0.41) | TNKS2MAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL13802559 | 0.76 | PBRM1 (0.51) | MAPTALDH1A1KDM4EKMT2AHSD17B10 | |
| SCHEMBL13802554 | 0.76 | PBRM1 (0.51) | MAPTALDH1A1KDM4EKMT2AHSD17B10 | |
| SCHEMBL5075710 | 0.75 | HDAC8 (0.45) | TNKS2HSD17B10HPGDALOX15 | |
| SCHEMBL5579420 | 0.75 | HDAC8 (0.45) | TNKS2HSD17B10HPGDALOX15 | |
| SCHEMBL5079009 | 0.75 | HDAC8 (0.45) | TNKS2HSD17B10HPGDALOX15 | |
| SCHEMBL5063195 | 0.75 | BRPF1 (0.67) | TNKS2PDGFRAFERLTKCDK8 | |
| SCHEMBL30592979 | 0.75 | BRPF1 (0.67) | TNKS2PDGFRAFERLTKCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070155730-A1 | Benzodiazepine And Benzopiperazine Analog Inhibitors Of Histone Deacetylase | METHYLGENE, INC. (CA) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155730-A1 | Benzodiazepine And Benzopiperazine Analog Inhibitors Of Histone Deacetylase | HDAC5, HDAC4, HDAC3 | TNKS2 2488/4885PDGFRA 3029/4885FER 4585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.