Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 2/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31031213 | 0.77 | PDE10A (0.39) | PKMKDM4EPOLBHSD17B10TP53 | |
| SCHEMBL22354956 | 0.75 | KDM4E (0.45) | KDM4EPOLBHSD17B10TP53LMNA | |
| SCHEMBL29822663 | 0.74 | KDM4E (0.46) | PKMKDM4EPOLBHSD17B10TP53 | |
| SCHEMBL31021114 | 0.72 | SMN1; SMN2 (0.52) | KDM4EPOLBHSD17B10TP53LMNA | |
| SCHEMBL537413 | 0.72 | SMN1; SMN2 (0.52) | KDM4EPOLBHSD17B10TP53LMNA | |
| SCHEMBL5001588 | 0.72 | KDM4E (0.54) | KDM4EPOLBHSD17B10TP53LMNA | |
| SCHEMBL28093697 | 0.72 | MAPT (0.43) | KDM4EPOLBHSD17B10TP53LMNA | |
| SCHEMBL19380387 | 0.71 | KDM4E (0.47) | PKMKDM4EPOLBLMNAMAPT | |
| Hydrochloric Acid SCHEMBL537828 | 0.71 | SMN1; SMN2 (0.50) | KDM4EPOLBHSD17B10TP53LMNA | |
| Hydrochloric Acid SCHEMBL537827 | 0.71 | SMN1; SMN2 (0.50) | KDM4EPOLBHSD17B10TP53LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3374358-A1 | AZETIDINE DERIVATIVES FOR TAU IMAGING | Eli Lilly and Company (US) | 2018-09-19 | — | — | EP | disclosed |
| WO-2017083198-A1 | AZETIDINE DERIVATIVES FOR TAU IMAGING | ELI LILLY AND COMPANY (US) | 2017-05-18 | — | — | WO | disclosed |
| US-20070148185-A1 | Novel therapeutic target for protozoal diseases | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY | 2007-06-28 | — | — | US | disclosed |