Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 9/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.40 |
| ▸ | CTSD | P07339 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5118540 | 0.88 | BACE1 (0.48) | MAPTBACE1TSHRLMNATP53 | |
| SCHEMBL5130832 | 0.86 | BACE1 (0.48) | BCHEACHEBACE1CTSD | |
| SCHEMBL5579727 | 0.84 | BACE1 (0.52) | BACE1CTSD | |
| SCHEMBL5130020 | 0.84 | BACE1 (0.52) | BACE1CTSD | |
| SCHEMBL5130530 | 0.83 | CTSD (0.43) | BCHEACHEBACE1CTSDMEN1 | |
| SCHEMBL5128239 | 0.83 | BACE1 (0.40) | BCHEACHEBACE1CTSD | |
| SCHEMBL5121726 | 0.82 | BACE1 (0.45) | BACE1CTSD | |
| SCHEMBL5130250 | 0.80 | BACE1 (0.47) | BACE1CTSD | |
| SCHEMBL5130257 | 0.80 | BACE1 (0.47) | BACE1CTSD | |
| SCHEMBL5130253 | 0.80 | BACE1 (0.47) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294642-B2 | 1,3-Diamino-2-hydroxypropane pro-drug derivatives | ELAN PHARMACEUTICALS, INC. (US) | 2007-11-13 | — | — | US | claimed |