Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 9/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.44 |
| ▸ | CTSD | P07339 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5124914 | 0.93 | BACE1 (0.43) | BACE1BACE2CTSDPOLBMAPT | |
| SCHEMBL5579978 | 0.89 | BACE1 (0.51) | BACE1BACE2CTSD | |
| SCHEMBL5131610 | 0.82 | BACE1 (0.52) | BACE1BACE2CTSDMAPT | |
| SCHEMBL5579825 | 0.81 | HPGD (0.48) | BACE1BACE2CTSDMAPTALDH1A1 | |
| SCHEMBL5128044 | 0.81 | BACE1 (0.47) | BACE1BACE2CTSDLPAR1HDAC1 | |
| SCHEMBL5127987 | 0.80 | BACE1 (0.45) | BACE1BACE2CTSDLPAR1HDAC1 | |
| SCHEMBL5118762 | 0.80 | BACE1 (0.46) | BACE1BACE2CTSDHDAC1HDAC6 | |
| SCHEMBL5117391 | 0.79 | BACE1 (0.53) | BACE1BACE2CTSD | |
| SCHEMBL5127601 | 0.79 | CTSD (0.49) | BACE1BACE2CTSD | |
| SCHEMBL5122817 | 0.78 | BACE1 (0.55) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7294642-B2 | 1,3-Diamino-2-hydroxypropane pro-drug derivatives | ELAN PHARMACEUTICALS, INC. (US) | 2007-11-13 | — | — | US | claimed |