Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 3/20 | 0.49 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.49 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | XDH | P47989 | 1/20 | 0.49 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PNP | P00491 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanine SCHEMBL17542296 | 0.92 | PNP (0.49) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL6227732 | 0.92 | PI4KA (0.41) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL906215 | 0.91 | PI4KA (0.59) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL4633068 | 0.91 | PI4KA (0.59) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL8860590 | 0.91 | PI4KA (0.59) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL2558881 | 0.88 | PI4KA (0.63) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Guanine SCHEMBL15718981 | 0.87 | PNP (0.43) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Adenine SCHEMBL4579097 | 0.86 | PI4KA (0.46) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Guanine SCHEMBL9468227 | 0.86 | PNP (0.43) | PI4KAPI4K2BPI4K2API4KBLRRK2 | |
| Guanine SCHEMBL6130674 | 0.82 | PNP (0.58) | PI4KAPI4K2BPI4K2API4KBLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070142277-A1 | Bace455, an alternative splice variant of the human beta-secretase | EXONHIT THERAPEUTICS SA (FR) | 2007-06-21 | — | — | US | disclosed |
| US-5693471-A | HYDROGEN BONDING | PRINCETON UNIVERSITY (US) | 1997-12-02 | — | — | US | disclosed |