Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 10/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5581490 | 0.95 | CTSS (0.41) | KDM4ECTSSALDH1A1MEN1HTT | |
| SCHEMBL6063127 | 0.87 | KDM4E (0.39) | KDM4ECTSSALDH1A1MEN1HTT | |
| SCHEMBL7043169 | 0.86 | CTSS (0.44) | KDM4ECTSS | |
| SCHEMBL5731264 | 0.85 | CTSS (0.40) | KDM4ECTSSALDH1A1MEN1HTT | |
| SCHEMBL6048169 | 0.82 | MEN1 (0.38) | KDM4ECTSSALDH1A1MEN1HTT | |
| SCHEMBL7116237 | 0.81 | CTSS (0.41) | KDM4ECTSSRAB9ASMN1; SMN2 | |
| SCHEMBL6062265 | 0.81 | CTSS (0.41) | KDM4ECTSSALDH1A1MEN1HTT | |
| SCHEMBL6461829 | 0.81 | CTSS (0.43) | KDM4ECTSS | |
| SCHEMBL6463182 | 0.81 | CTSS (0.43) | KDM4ECTSSFAAHCES1 | |
| SCHEMBL14523317 | 0.80 | CTSS (0.43) | KDM4ECTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007519744-A | — | — | 2007-07-19 | — | — | JP | claimed |
| EP-1716158-A2 | SILINANE COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS | Schering Aktiengesellschaft (DE) | 2006-11-02 | — | — | EP | claimed |
| WO-2005074904-A2 | SILINANE COMPOUNDS AS CYSTEINE PROTEASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-08-18 | — | — | WO | claimed |