Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Methionine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BHMT | Q93088 | 10/20 | 0.40 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.39 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | NOS3 | P29474 | 2/20 | 0.34 |
| ▸ | NOS1 | P29475 | 2/20 | 0.34 |
| ▸ | GSR | P00390 | 2/20 | 0.33 |
| ▸ | GRM8 | O00222 | 1/20 | 0.33 |
| ▸ | GRM6 | O15303 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Racemethionine SCHEMBL692979 | 1.00 | BHMT (0.40) | BHMTBHMT2RNPEPNOS2NOS3 | |
| Methionine SCHEMBL692981 | 1.00 | BHMT (0.40) | BHMTBHMT2RNPEPNOS2NOS3 | |
| Methionine SCHEMBL6361609 | 0.97 | BHMT (0.42) | BHMTBHMT2RNPEPNOS2NOS3 | |
| Racemethionine SCHEMBL6361604 | 0.97 | BHMT (0.42) | BHMTBHMT2RNPEPNOS2NOS3 | |
| Racemethionine SCHEMBL3995865 | 0.95 | BHMT (0.43) | BHMTBHMT2RNPEPNOS2NOS3 | |
| Methionine SCHEMBL3995878 | 0.95 | BHMT (0.43) | BHMTBHMT2RNPEPNOS2NOS3 | |
| Racemethionine SCHEMBL4361129 | 0.92 | BHMT (0.46) | BHMTBHMT2RNPEPNOS2NOS3 | |
| Methionine SCHEMBL4361132 | 0.92 | BHMT (0.46) | BHMTBHMT2RNPEPNOS2NOS3 | |
| Racemethionine SCHEMBL7953819 | 0.92 | BHMT (0.45) | BHMTBHMT2RNPEPNOS2NOS3 | |
| Racemethionine SCHEMBL27729867 | 0.92 | BHMT (0.45) | BHMTBHMT2RNPEPNOS2NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070264627-A1 | Retrovirus from the HIV group and its use | DADE BEHRING MARBURG GMBH | 2007-11-15 | — | — | US | claimed |
| US-20070105219-A1 | Retrovirus from the HIV group and its use | DADE BEHRING MARBURG GMBH | 2007-05-10 | — | — | US | claimed |