Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FUT7 | Q11130 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.32 |
| ▸ | GLS2 | Q9UI32 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5186796 | 1.00 | FUT7 (0.40) | FUT7KCNH2RECQLGLAHPGD | |
| SCHEMBL61178 | 0.94 | FUT7 (0.33) | FUT7KCNH2RECQLGLAHPGD | |
| Sulfuric Acid SCHEMBL2554779 | 0.89 | KCNH2 (0.39) | FUT7KCNH2GPR84CA2 | |
| SCHEMBL5961710 | 0.88 | RECQL (0.53) | FUT7KCNH2RECQLGLAHPGD | |
| SCHEMBL5961715 | 0.88 | RECQL (0.53) | FUT7KCNH2RECQLGLAHPGD | |
| SCHEMBL5961714 | 0.88 | RECQL (0.53) | FUT7KCNH2RECQLGLAHPGD | |
| SCHEMBL2453688 | 0.88 | RECQL (0.53) | FUT7KCNH2RECQLGLAHPGD | |
| SCHEMBL20288 | 0.85 | RECQL (0.53) | FUT7KCNH2RECQLGLAHPGD | |
| SCHEMBL5961699 | 0.85 | RECQL (0.53) | FUT7KCNH2RECQLGLAHPGD | |
| Sulfuric Acid SCHEMBL5983597 | 0.85 | CA2 (0.34) | KCNH2HPGDCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805206-A2 | ELECTROCHEMICAL DEBLOCKING USING A HYDRAZINE DERIVATIVE | Combimatrix Corporation (US) | 2007-07-11 | — | — | EP | claimed |
| WO-2006031814-A2 | ELECTROCHEMICAL DEBLOCKING USING A HYDRAZINE DERIVATIVE | COMBIMATRIX CORPORATION (US) | 2006-03-23 | — | — | WO | claimed |
| EP-3229959-A1 | HIGH EFFICIENCY, SMALL VOLUME NUCLEIC ACID SYNTHESIS | Life Technologies Corporation (US) | 2017-10-18 | — | — | EP | disclosed |
| WO-2016094512-A1 | HIGH EFFICIENCY, SMALL VOLUME NUCLEIC ACID SYNTHESIS | yLIFE TECHNOLOGIES CORPORATION (US) | 2016-06-16 | — | — | WO | disclosed |
| EP-1805206-A2 | ELECTROCHEMICAL DEBLOCKING USING A HYDRAZINE DERIVATIVE | Combimatrix Corporation (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006031814-A2 | ELECTROCHEMICAL DEBLOCKING USING A HYDRAZINE DERIVATIVE | COMBIMATRIX CORPORATION (US) | 2006-03-23 | — | — | WO | disclosed |