⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL7414302 | 0.86 | — | — | |
| SCHEMBL3969262 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL3963502 | 0.79 | — | — | |
| Pyrrole SCHEMBL18797670 | 0.72 | — | — | |
| SCHEMBL460674 | 0.69 | — | — | |
| SCHEMBL3542282 | 0.67 | — | — | |
| SCHEMBL16238310 | 0.67 | — | — | |
| SCHEMBL8428656 | 0.64 | KMT2A (0.36) | — | |
| SCHEMBL8902925 | 0.64 | HTT (0.32) | — | |
| SCHEMBL5912864 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5880122-A | TREATING DISEASES CHARACTERIZED BY EXCESS RENAL REABSORPTION OF WATER | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-03-09 | — | — | US | claimed |
| US-4118386-A | Synthesis of imidazo[1,5-a]diazepine-3-carboxylates | HOFFMANN-LA ROCHE INC. (US) | 1978-10-03 | — | — | US | claimed |
| CN-118146289-A | Positive and negative regulation NAMPT and NAD+Optically controlled PROTAC compounds and uses thereof | 中国人民解放军海军军医大学 | 2024-06-07 | — | — | CN | disclosed |
| CN-112601749-B | Benzodiazepine derivatives, compositions and methods for treating cognitive impairment | 艾吉因生物股份有限公司 | 2024-03-26 | — | — | CN | disclosed |
| EP-3654968-B1 | METALLO-BETA-LACTAMASE INHIBITORS AND METHODS OF USE THEREOF | MERCK SHARP & DOHME LLC (US) | 2023-08-16 | — | — | EP | disclosed |
| EP-3313828-B1 | METALLO-BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-07-12 | — | — | EP | disclosed |
| CN-115433211-A | Pyrazidopyridone methionine adenosyltransferase 2A inhibitors | 南京正大天晴制药有限公司 | 2022-12-06 | — | — | CN | disclosed |
| CN-115151561-A | Targeted autophagy conjugates and methods | 前沿药品公司 | 2022-10-04 | — | — | CN | disclosed |
| CN-109790170-B | GABA (A) receptor modulators and methods of controlling airway hyperresponsiveness and inflammation in asthma | UWM研究基金会有限公司 | 2022-08-02 | — | — | CN | disclosed |
| US-20210289794-A1 | COMPOSITIONS AND RELATED METHODS FOR AGRICULTURE | FLAGSHIP PIONEERING INNOVATIONS V, INC. | 2021-09-23 | — | — | US | disclosed |
| WO-2016154031-A1 | GABAERGIC LIGANDS AND THEIR USES | UWM RESEARCH FOUNDATION, INC. (US) | 2016-09-29 | — | — | WO | disclosed |
| CN-1197849-C | 2,3,4,5-tetrahydro-1H-[1,4] benzodiazepine-3-hydroxamic acid as matrix metalloproteinase inhibitors | AMERICAN CYANAMID CO (US) | 2005-04-20 | — | — | CN | disclosed |
| WO-2004017908-A2 | CALCIUM RECEPTOR MODULATING COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-04 | — | — | WO | disclosed |
| CN-1337952-A | 2,3,4, 5-tetrahydro-1H- [1,4] benzodiazepine-3-hydroxamic acids as matrix metalloproteinase inhibitors | AMERICAN CYANAMID CO (US) | 2002-02-27 | — | — | CN | disclosed |
| EP-1021444-A1 | 3-CARBOXAMIDE DERIVATIVES OF 5H-PYRROLO[2,1-c][1,4]-BENZODIAZEPINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-26 | — | — | EP | disclosed |
| US-5962450-A | SEDATIVE | HOFFMANN-LA ROCHE INC. (US) | 1999-10-05 | — | — | US | disclosed |
| US-5885986-A | CLEAVING, N-ALKYLATING AND REDUCING THE INTERMEDIATE FORMED BY REACTING AN OXAZOLYL AND THIAZOLYLIMIDAZOBENZO AND THIENODIAZEPINE DERIVATIVES WITH AMINE COMPOUNDS; USED AS ANXIOLYTIC AND ANTICONVULSANT OR SEDATIVE-HYPNOTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1999-03-23 | — | — | US | disclosed |
| US-5880122-A | TREATING DISEASES CHARACTERIZED BY EXCESS RENAL REABSORPTION OF WATER | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-03-09 | — | — | US | disclosed |
| WO-1998020011-A1 | 3-CARBOXAMIDE DERIVATIVES OF 5H-PYRROLO[2,1-c][1,4]-BENZODIAZEPINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-05-14 | — | — | WO | disclosed |
| US-4118386-A | Synthesis of imidazo[1,5-a]diazepine-3-carboxylates | HOFFMANN-LA ROCHE INC. (US) | 1978-10-03 | — | — | US | disclosed |