Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5583489 | 0.86 | — | — | |
| SCHEMBL3969262 | 0.73 | — | — | |
| SCHEMBL460674 | 0.72 | — | — | |
| Piperazine SCHEMBL7421299 | 0.69 | GABRP (0.30) | — | |
| Piperazine SCHEMBL7418941 | 0.66 | MAPT (0.33) | — | |
| Azetidine SCHEMBL29508436 | 0.61 | TSHR (0.38) | — | |
| SCHEMBL8428656 | 0.59 | KMT2A (0.36) | — | |
| SCHEMBL8902925 | 0.59 | HTT (0.32) | — | |
| SCHEMBL5912864 | 0.57 | — | — | |
| SCHEMBL16850625 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5880122-A | TREATING DISEASES CHARACTERIZED BY EXCESS RENAL REABSORPTION OF WATER | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-03-09 | — | — | US | claimed |
| US-5880122-A | TREATING DISEASES CHARACTERIZED BY EXCESS RENAL REABSORPTION OF WATER | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-03-09 | — | — | US | disclosed |