Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL210723 | 0.93 | SMN1; SMN2 (0.34) | LMNAGAASMN1; SMN2 | |
| SCHEMBL8280225 | 0.68 | SMN1; SMN2 (0.34) | LMNAGAASMN1; SMN2 | |
| SCHEMBL8280226 | 0.66 | GRIA1 (0.39) | LMNAGAASMN1; SMN2 | |
| SCHEMBL13439215 | 0.64 | — | — | |
| SCHEMBL3554359 | 0.61 | — | — | |
| SCHEMBL3233034 | 0.61 | — | — | |
| SCHEMBL2759501 | 0.60 | SMN1; SMN2 (0.35) | LMNASMN1; SMN2 | |
| SCHEMBL2733511 | 0.59 | SMN1; SMN2 (0.34) | SMN1; SMN2 | |
| SCHEMBL6050412 | 0.57 | SMN1; SMN2 (0.33) | LMNASMN1; SMN2 | |
| SCHEMBL5766410 | 0.56 | SMN1; SMN2 (0.35) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253204-B2 | Antiproliferative agents | METHYLGENE INC. (CA) | 2007-08-07 | — | — | US | disclosed |
| US-20050245518-A1 | Antiproliferative agents | METHYLGENE, INC. | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245518-A1 | Antiproliferative agents | HDAC1, HDAC11, HDAC5 | LMNA 1851/4885GAA 144/4885SMN1; SMN2 2705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.