Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL210723 | 0.74 | SMN1; SMN2 (0.34) | SMN1; SMN2MAPK1LMNAGAAMAPT | |
| SCHEMBL8280226 | 0.69 | GRIA1 (0.39) | SMN1; SMN2MAPK1LMNAGAAMAPT | |
| SCHEMBL5584042 | 0.67 | KMT2A (0.37) | SMN1; SMN2LMNAGAAMAPT | |
| SCHEMBL4373865 | 0.65 | — | — | |
| SCHEMBL7055952 | 0.62 | — | — | |
| SCHEMBL4373863 | 0.62 | — | — | |
| SCHEMBL16109360 | 0.62 | — | — | |
| SCHEMBL2759602 | 0.61 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPK1LMNAGAAMAPT | |
| SCHEMBL25431203 | 0.57 | AKR1B1 (0.30) | — | |
| SCHEMBL11310557 | 0.53 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088805-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2012-01-03 | — | — | US | disclosed |
| WO-2005092899-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2005-10-06 | — | — | WO | disclosed |