Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211035 | 1.00 | ALDH1A1 (0.48) | ALDH1A1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL210860 | 0.80 | DHODH (0.38) | ALDH1A1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL20452073 | 0.80 | ALDH1A1 (0.58) | ALDH1A1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL4159119 | 0.80 | ALDH1A1 (0.58) | ALDH1A1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL212100 | 0.77 | LCK (0.54) | ALDH1A1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL26058046 | 0.75 | APEX1 (0.37) | PAX8 | |
| SCHEMBL4161633 | 0.75 | ALDH1A1 (0.53) | ALDH1A1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL2076090 | 0.73 | ALDH1A1 (0.61) | ALDH1A1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL14955176 | 0.73 | ALDH1A1 (0.61) | ALDH1A1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL24410214 | 0.73 | USP30 (0.33) | PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253204-B2 | Antiproliferative agents | METHYLGENE INC. (CA) | 2007-08-07 | — | — | US | disclosed |
| US-20050245518-A1 | Antiproliferative agents | METHYLGENE, INC. | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245518-A1 | Antiproliferative agents | HDAC1, HDAC11, HDAC5 | ALDH1A1 758/4885RAB9A 3239/4885SMN1; SMN2 2705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.