Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 6/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2719589 | 0.92 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL4946888 | 0.88 | IL2 (0.41) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL14028120 | 0.87 | MAPK14 (0.48) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL14046335 | 0.87 | MAPK13 (0.41) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL5584200 | 0.87 | MAPK14 (0.39) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL14303659 | 0.86 | RXFP1 (0.35) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL2719310 | 0.85 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL2721566 | 0.84 | LMNA (0.41) | MAPK14KDM4E | |
| SCHEMBL2720187 | 0.84 | MAPK14 (0.40) | MAPK14MAPK13MAPK12MAPK11KCNH2 | |
| SCHEMBL2720800 | 0.84 | MAPK14 (0.37) | MAPK14MAPK13MAPK12MAPK11KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2447266-A1 | Pyrimidopyridine compound used as a CSBP/RK/p38 modulator | GLAXO GROUP LIMITED (GB) | 2012-05-02 | — | — | EP | disclosed |
| WO-2006104915-A9 | 8-PHENYL-7,8-DIHYDROPYRIDO[2,3-d]PYRIMIDIN-7-ONES AND THEIR USE AS PHARMACEUTICALS | GLAXO GROUP LTD (GB) | 2008-01-03 | — | — | WO | disclosed |