Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 9/20 | 0.51 |
| ▸ | MEN1 | O00255 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | ACP1 | P24666 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL211848 | 0.93 | HDAC1 (0.56) | KMT2ADYRK1AMAPTMEN1ALDH1A1 | |
| SCHEMBL3949427 | 0.82 | DYRK1A (0.70) | KMT2ADYRK1AMAPTMEN1ALDH1A1 | |
| SCHEMBL30493298 | 0.82 | DYRK1A (0.70) | KMT2ADYRK1AMAPTMEN1ALDH1A1 | |
| SCHEMBL210651 | 0.81 | HDAC1 (0.64) | KMT2AMEN1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2733780 | 0.81 | HDAC1 (0.61) | ALDH1A1SMN1; SMN2NPC1RAB9AHDAC1 | |
| SCHEMBL211650 | 0.80 | HDAC1 (0.60) | DYRK1AHDAC1 | |
| SCHEMBL5001543 | 0.79 | RIPK1 (0.63) | KMT2ADYRK1AMAPTMEN1ALDH1A1 | |
| SCHEMBL31068560 | 0.77 | RIPK1 (0.66) | KMT2ADYRK1AMAPTMEN1ALDH1A1 | |
| SCHEMBL211614 | 0.77 | HDAC1 (0.74) | MAPTALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL2733518 | 0.77 | HDAC1 (0.58) | DYRK1AHTTHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253204-B2 | Antiproliferative agents | METHYLGENE INC. (CA) | 2007-08-07 | — | — | US | disclosed |
| US-20050245518-A1 | Antiproliferative agents | METHYLGENE, INC. | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245518-A1 | Antiproliferative agents | HDAC1, HDAC11, HDAC5 | KMT2A 123/4885DYRK1A 3550/4885MAPT 3905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.