Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.69 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.63 |
| ▸ | CA12 | O43570 | 1/20 | 0.62 |
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
| ▸ | CA4 | P22748 | 1/20 | 0.62 |
| ▸ | CA6 | P23280 | 1/20 | 0.62 |
| ▸ | CA7 | P43166 | 1/20 | 0.62 |
| ▸ | TPMT | P51580 | 1/20 | 0.62 |
| ▸ | CA9 | Q16790 | 1/20 | 0.62 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5585560 | 1.00 | ABCG2 (0.69) | ABCG2TNFRSF1AMAPTLMNAABCB1 | |
| SCHEMBL5585584 | 0.88 | TNFRSF1A (0.75) | ABCG2TNFRSF1AMAPTLMNAABCB1 | |
| SCHEMBL5585582 | 0.88 | TNFRSF1A (0.75) | ABCG2TNFRSF1AMAPTLMNAABCB1 | |
| SCHEMBL10812154 | 0.88 | TSHR (0.68) | ABCG2TNFRSF1AMAPTLMNAABCB1 | |
| SCHEMBL11122437 | 0.88 | TSHR (0.68) | ABCG2TNFRSF1AMAPTLMNAABCB1 | |
| SCHEMBL10764854 | 0.88 | PDE4A (0.60) | ABCG2TNFRSF1AMAPTLMNAABCB1 | |
| SCHEMBL10764858 | 0.88 | PDE4A (0.60) | ABCG2TNFRSF1AMAPTLMNAABCB1 | |
| SCHEMBL10989842 | 0.87 | HTT (0.65) | ABCG2CA12CA1CA2CA4 | |
| SCHEMBL9037753 | 0.87 | MAPT (0.54) | ABCG2TNFRSF1AMAPTLMNAABCB1 | |
| SCHEMBL5585546 | 0.86 | ABCG2 (0.69) | ABCG2TNFRSF1AMAPTLMNAABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108658765-A | A kind of 4-（3,4- Dimethoxyphenyls）The preparation method of -4- oxo -2- butenoic acid ethyls | 黄石市利福达医药化工有限公司 | 2018-10-16 | — | — | CN | claimed |
| US-4483868-A | ANTIULCER AGENTS ANTISECRETORY AGENTS | ROUSSEL UCLAF (FR) | 1984-11-20 | — | — | US | claimed |
| CN-108658765-B | Preparation method of 4- (3, 4-dimethoxyphenyl) -4-oxo-2-ethyl crotonate | 黄石市利福达医药化工有限公司 | 2021-03-16 | — | — | CN | disclosed |
| CN-108658765-A | A kind of 4-（3,4- Dimethoxyphenyls）The preparation method of -4- oxo -2- butenoic acid ethyls | 黄石市利福达医药化工有限公司 | 2018-10-16 | — | — | CN | disclosed |
| CN-106860441-A | Application of the crotonamide derivative of 4 oxo 2 in bacteriostatic agent is prepared | 中国医学科学院医药生物技术研究所 | 2017-06-20 | — | — | CN | disclosed |
| US-7161022-B2 | Process for producing 4-phenyl-4-oxo-2-butenoic ester derivative | FUJIFILM FINECHEMICALS CO., LTD. (JP) | 2007-01-09 | — | — | US | disclosed |
| US-20050176994-A1 | Process for producing 4-phenyl-4-oxo-2-butenoic ester derivative | SANKIO CHEMICAL CO., LTD. (JP) | 2005-08-11 | — | — | US | disclosed |
| EP-1505054-A1 | PROCESS FOR PRODUCING 4-PHENYL-4-OXO-2-BUTENOIC ESTER DERIVATIVE | Sankio Chemical Co., Ltd. (JP) | 2005-02-09 | — | — | EP | disclosed |
| EP-0902011-B1 | GAMMA-OXO-HOMOPHENYLALANINE DERIVATIVES AND PROCESS FOR PRODUCING HOMOPHENYLALANINE DERIVATIVES BY REDUCING THE SAME | KANEKA CORP (JP) | 2003-05-21 | — | — | EP | disclosed |
| US-5981794-A | REACTING A BETA-BENZOYLACRYLIC ACID DERIVATIVE WITH A 1-ARYLETHYLAMINE DERIVATIVE | KANEKA CORPORATION (JP) | 1999-11-09 | — | — | US | disclosed |
| EP-0902011-A1 | $g(g)-OXO-HOMOPHENYLALANINE DERIVATIVES AND PROCESS FOR PRODUCING HOMOPHENYLALANINE DERIVATIVES BY REDUCING THE SAME | Kaneka Corporation (JP) | 1999-03-17 | — | — | EP | disclosed |
| EP-0138349-B1 | 3-BENZOYL-2-MERCAPTOPROPIONIC ACID DERIVATIES | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1986-11-12 | — | — | EP | disclosed |
| US-4594197-A | 3-benzoyl-2-mercaptopropionic acid derivatives | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1986-06-10 | — | — | US | disclosed |
| EP-0138349-A1 | 3-Benzoyl-2-mercaptopropionic acid derivaties | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1985-04-24 | — | — | EP | disclosed |
| US-4483868-A | ANTIULCER AGENTS ANTISECRETORY AGENTS | ROUSSEL UCLAF (FR) | 1984-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176994-A1 | Process for producing 4-phenyl-4-oxo-2-butenoic ester derivative | HPD, PAH, CYP4A11 | ABCG2 2485/4885TNFRSF1A 4317/4885MAPT 2392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.