Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 13/20 | 0.79 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1872761 | 0.94 | MAPK14 (0.84) | MAPK14MAPK9MAPK10MAPK11NPC1 | |
| SCHEMBL1877548 | 0.90 | MAPK14 (0.81) | MAPK14MAPK9MAPK10MAPK11NPC1 | |
| SCHEMBL1882877 | 0.90 | MAPK14 (0.79) | MAPK14MAPK9MAPK10MAPK11NPC1 | |
| SCHEMBL1877324 | 0.89 | MAPK14 (1.00) | MAPK14MAPK9MAPK10MAPK11 | |
| SCHEMBL1881717 | 0.89 | MAPK14 (0.81) | MAPK14MAPK9MAPK10MAPK11PRKACA | |
| SCHEMBL1881306 | 0.89 | MAPK14 (0.81) | MAPK14MAPK9MAPK10MAPK11POLB | |
| SCHEMBL5586148 | 0.88 | MAPK14 (0.77) | MAPK14MAPK9MAPK10MAPK11 | |
| SCHEMBL1876160 | 0.87 | MAPK14 (0.76) | MAPK14MAPK9MAPK10MAPK11CYP3A4 | |
| SCHEMBL1880979 | 0.87 | MAPK14 (0.79) | MAPK14MAPK9MAPK10MAPK11 | |
| SCHEMBL1884134 | 0.86 | MAPK14 (0.77) | MAPK14MAPK9MAPK10MAPK11CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1832584-A1 | PYRIMIDINYLISOXAZOL DERIVATIVE | ASKA Pharmaceutical Co., Ltd. (JP) | 2007-09-12 | — | — | EP | disclosed |