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SCHEMBL5590648

SCHEMBL5590648

CC(C)(C)S(=O)(=O)c1ccc2ncc(C(N)=O)c(Nc3cncc(Cl)c3)c2c1.CCc1cc(S(C)(=O)=O)cc2c(Nc3ccc(F)c(OC)c3)c(C(N)=O)cnc12

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ PDE4B Q07343 12/20 0.65
▸ CSF1R P07333 8/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2475119 0.85 PDE4B (0.83) PDE4BCSF1R
SCHEMBL2481344 0.81 PDE4B (0.63) PDE4BCSF1R
SCHEMBL1275623 0.80 PDE4B (1.00) PDE4BCSF1R
SCHEMBL1275858 0.78 PDE4B (0.85) PDE4BCSF1R
SCHEMBL1275852 0.76 PDE4B (1.00) PDE4BCSF1R
SCHEMBL14198945 0.74 PDE4B (0.83) PDE4BCSF1R
SCHEMBL4951386 0.74 PDE4B (0.74) PDE4BCSF1R
SCHEMBL4948827 0.74 PDE4B (0.71) PDE4BCSF1R
Hydrochloric Acid SCHEMBL4625816 0.74 PDE4B (0.82) PDE4BCSF1R
SCHEMBL2480619 0.73 PDE4B (0.46) PDE4BCSF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2007501264-A — — 2007-01-25 — — JP claimed
EP-1633748-A1 QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS GLAXO GROUP LIMITED (GB) 2006-03-15 — — EP claimed
WO-2004103998-A1 QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS GLAXO GROUP LIMITED (GB) 2004-12-02 — — WO claimed