Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 18/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL474161 | 0.80 | MPL (1.00) | MPL | |
| SCHEMBL5999201 | 0.77 | MPL (0.61) | MPLCYP3A4CYP2D6CYP2C9SCN9A | |
| SCHEMBL8117023 | 0.74 | MPL (0.67) | MPLCYP3A4CYP2D6CYP2C9SCN9A | |
| SCHEMBL6686667 | 0.73 | HTR2B (0.56) | CYP3A4CYP2D6CYP2C9SCN9A | |
| SCHEMBL4367503 | 0.73 | SMN1; SMN2 (0.55) | MPLCYP3A4CYP2D6CYP2C9SCN9A | |
| SCHEMBL7432599 | 0.72 | HTR2C (0.60) | MPLCYP3A4CYP2D6CYP2C9SCN9A | |
| SCHEMBL7440522 | 0.72 | CYP3A4 (0.61) | CYP3A4CYP2D6CYP2C9SCN9A | |
| SCHEMBL1198042 | 0.72 | MPL (0.53) | MPL | |
| SCHEMBL5446093 | 0.72 | SCN9A (0.66) | MPLCYP3A4CYP2D6CYP2C9SCN9A | |
| SCHEMBL6660568 | 0.72 | ATP4A (0.58) | CYP3A4CYP2D6CYP2C9SCN9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007004038-A1 | AMINOTHIAZOLE DERIVATIVES AS AGONISTS OF THE THROMBOPOIETIN RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-01-11 | — | — | WO | claimed |
| WO-2007004038-A1 | AMINOTHIAZOLE DERIVATIVES AS AGONISTS OF THE THROMBOPOIETIN RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-01-11 | — | — | WO | disclosed |