Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 9/20 | 0.42 |
| ▸ | AURKA | O14965 | 4/20 | 0.42 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.39 |
| ▸ | PAK4 | O96013 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14606049 | 0.85 | PAK4 (0.49) | GRK6AURKAPLK4PAK4IGF1R | |
| SCHEMBL14605943 | 0.82 | PLK4 (0.38) | GRK6AURKAPLK4PAK4HRH3 | |
| SCHEMBL14605903 | 0.81 | PAK1 (0.38) | GRK6AURKAPLK4PAK4HRH3 | |
| SCHEMBL3852749 | 0.78 | GRK6 (0.41) | GRK6AURKAPLK4PAK4IGF1R | |
| SCHEMBL5591240 | 0.77 | RET (0.40) | GRK6AURKAPLK4PAK4GRIA2 | |
| SCHEMBL5768922 | 0.74 | GRK6 (0.41) | GRK6AURKAPLK4PAK4IGF1R | |
| SCHEMBL3852023 | 0.72 | GRK6 (0.42) | GRK6AURKAPLK4PAK4IGF1R | |
| SCHEMBL5591814 | 0.72 | HRH3 (0.47) | YTHDC1HRH3GRIA2GRIN1GRIN2A | |
| SCHEMBL3849950 | 0.71 | GRK6 (0.42) | GRK6AURKAPLK4PAK4IGF1R | |
| SCHEMBL5822082 | 0.71 | GRK6 (0.42) | GRK6AURKAPLK4PAK4IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007023382-A2 | PYRIMIDINE AMINO PYRAZOLE COMPOUNDS, POTENT KINASE INHIBITORS | PFIZER INC. (US) | 2007-03-01 | — | — | WO | disclosed |
| WO-2007023382-A2 | PYRIMIDINE AMINO PYRAZOLE COMPOUNDS, POTENT KINASE INHIBITORS | PFIZER INC. (US) | 2007-03-01 | — | — | WO | disclosed |