Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 3/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 2/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | GRK6 | P43250 | 1/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14605943 | 0.90 | PLK4 (0.38) | PAK1LCKITKAURKBPAK4 | |
| SCHEMBL5591240 | 0.88 | RET (0.40) | LCKITKAURKBPAK4PLK4 | |
| SCHEMBL5591517 | 0.81 | GRK6 (0.42) | PAK4PLK4AURKAGRK6NLRP3 | |
| SCHEMBL14605910 | 0.74 | AURKB (0.39) | PAK1LCKITKAURKBPAK4 | |
| SCHEMBL14605960 | 0.74 | LCK (0.50) | PAK1LCKITKAURKBPAK4 | |
| SCHEMBL14605898 | 0.74 | LCK (0.62) | PAK1LCKITKAURKBPAK4 | |
| SCHEMBL14605967 | 0.70 | RET (0.43) | PAK1LCKITKAURKBPAK4 | |
| SCHEMBL14606069 | 0.70 | AURKB (0.46) | PAK1LCKITKAURKBPAK4 | |
| SCHEMBL14606105 | 0.70 | LCK (0.46) | LCKITKAURKBPAK4PLK4 | |
| SCHEMBL14605947 | 0.69 | AURKB (0.54) | PAK1LCKITKAURKBPAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007023382-A2 | PYRIMIDINE AMINO PYRAZOLE COMPOUNDS, POTENT KINASE INHIBITORS | PFIZER INC. (US) | 2007-03-01 | — | — | WO | disclosed |