Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 11/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5579002 | 0.81 | HDAC1 (0.59) | HDAC1HDAC6HDAC8PDE4B | |
| SCHEMBL20955066 | 0.75 | NOTUM (0.44) | HDAC1HDAC6HDAC8 | |
| SCHEMBL5578983 | 0.70 | HDAC1 (0.53) | HDAC1HDAC6HDAC8PDE4B | |
| SCHEMBL13227805 | 0.69 | HDAC1 (0.64) | HDAC1HDAC6HDAC8ALDH1A1 | |
| SCHEMBL5578644 | 0.69 | HDAC1 (0.49) | HDAC1HDAC6HDAC8 | |
| SCHEMBL5578763 | 0.69 | HDAC1 (0.53) | HDAC1HDAC6RIPK1 | |
| SCHEMBL5578911 | 0.68 | HDAC1 (0.49) | HDAC1HDAC6HDAC8 | |
| SCHEMBL5578836 | 0.68 | SMN1; SMN2 (0.57) | HDAC1HDAC6ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL11096094 | 0.68 | RIPK1 (0.49) | HDAC1HDAC6RIPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL13228097 | 0.68 | HDAC1 (0.54) | HDAC1HDAC6HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |