Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.45 |
| ▸ | CDK2 | P24941 | 4/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | CDK7 | P50613 | 3/20 | 0.42 |
| ▸ | CCNH | P51946 | 3/20 | 0.42 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.42 |
| ▸ | CCNK | O75909 | 2/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 4/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | JUN | P05412 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL559285 | 1.00 | MAPK8 (0.45) | MAPK8MAPK10MAPK9CDK2CCNA2 | |
| SCHEMBL10166348 | 1.00 | MAPK8 (0.45) | MAPK8MAPK10MAPK9CDK2CCNA2 | |
| SCHEMBL10166347 | 0.81 | MAPK1 (0.45) | MAPK8MAPK10MAPK9CDK2CCNA2 | |
| SCHEMBL559773 | 0.81 | MAPK1 (0.45) | MAPK8MAPK10MAPK9CDK2CCNA2 | |
| SCHEMBL559774 | 0.81 | MAPK1 (0.45) | MAPK8MAPK10MAPK9CDK2CCNA2 | |
| SCHEMBL558852 | 0.80 | HPGDS (0.56) | MAPK8MAPK10MAPK9CDK2CCNA2 | |
| SCHEMBL558853 | 0.80 | HPGDS (0.56) | MAPK8MAPK10MAPK9CDK2CCNA2 | |
| SCHEMBL559323 | 0.77 | MAPK8 (0.46) | MAPK8MAPK10MAPK9CDK2CCNA2 | |
| SCHEMBL559324 | 0.77 | MAPK8 (0.46) | MAPK8MAPK10MAPK9CDK2CCNA2 | |
| SCHEMBL12361586 | 0.76 | MAPK8 (0.46) | MAPK8MAPK10MAPK9CDK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035194-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER INC. (US) | 2012-02-09 | — | — | US | disclosed |
| US-7998978-B2 | Substituted 2-amino-fused heterocyclic compounds | PFIZER INC. (US) | 2011-08-16 | — | — | US | disclosed |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035194-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | MAPK8 20/4885MAPK10 32/4885MAPK9 62/4885 |
| US-20100056506-A1 | SUBSTITUTED 2-AMINO-FUSED HETEROCYCLIC COMPOUNDS | MAPK1, SLC5A1, ATF1 | MAPK8 20/4885MAPK10 32/4885MAPK9 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.