Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
| ▸ | S1PR2 | O95136 | 4/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5593101 | 0.93 | MAPT (0.43) | MAPTEPHB4S1PR2NTRK1NTRK2 | |
| SCHEMBL5592585 | 0.90 | MEN1 (0.47) | MAPTEPHB4NTRK1NTRK2POLB | |
| SCHEMBL5592480 | 0.88 | EPHB4 (0.47) | MAPTEPHB4MEN1KMT2AIGF1R | |
| SCHEMBL5592642 | 0.87 | EPHB4 (0.40) | MAPTEPHB4MEN1KMT2ATP53 | |
| Ji-101 SCHEMBL5585996 | 0.86 | EPHB4 (0.46) | MAPTEPHB4MEN1KMT2AIRAK4 | |
| Ji-101 SCHEMBL29375077 | 0.86 | EPHB4 (0.46) | MAPTEPHB4MEN1KMT2AIRAK4 | |
| Ji-101 SCHEMBL14993319 | 0.86 | EPHB4 (0.45) | MAPTEPHB4MEN1KMT2AIRAK4 | |
| SCHEMBL5592483 | 0.85 | EPHB4 (0.42) | MAPTEPHB4MEN1KMT2ALMNA | |
| SCHEMBL5586075 | 0.84 | KDR (0.47) | MAPTEPHB4MEN1KMT2ALMNA | |
| SCHEMBL166253 | 0.84 | EPHB4 (0.42) | MAPTEPHB4NTRK1NTRK2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858879-B1 | 1,3-DIARYL SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT INC (US) | 2012-06-06 | — | — | EP | claimed |
| CN-102267978-A | 1,3-diaryl substituted ureas as modulators of kinase activity | — | 2011-12-07 | — | — | CN | claimed |
| CN-101163691-A | 1, 3-diaryl substituted ureas as modulators of kinase activity | CGI PHARMACEUTICALS INC (US) | 2008-04-16 | — | — | CN | claimed |
| EP-1858879-A1 | 1,3-DIARYL SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | CGI Pharmaceuticals, Inc. (US) | 2007-11-28 | — | — | EP | claimed |
| US-20060199846-A1 | Certain substituted ureas as modulators of kinase activity | GILEAD CONNECTICUT, INC. | 2006-09-07 | — | — | US | claimed |
| WO-2006076593-A1 | 1,3-DIARYL SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | CGI PHARMACEUTICALS, INC. (US) | 2006-07-20 | — | — | WO | claimed |
| EP-1858879-B1 | 1,3-DIARYL SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT INC (US) | 2012-06-06 | — | — | EP | disclosed |
| EP-1858879-B1 | 1,3-DIARYL SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT INC (US) | 2012-06-06 | — | — | EP | disclosed |
| EP-2397478-A1 | 1,3-diaryl substituted ureas as modulators of kinase activity. | CGI Pharmaceuticals, Inc. (US) | 2011-12-21 | — | — | EP | disclosed |
| EP-2397478-A1 | 1,3-diaryl substituted ureas as modulators of kinase activity. | CGI Pharmaceuticals, Inc. (US) | 2011-12-21 | — | — | EP | disclosed |
| CN-102267978-A | 1,3-diaryl substituted ureas as modulators of kinase activity | — | 2011-12-07 | — | — | CN | disclosed |
| CN-101163691-A | 1, 3-diaryl substituted ureas as modulators of kinase activity | CGI PHARMACEUTICALS INC (US) | 2008-04-16 | — | — | CN | disclosed |
| US-20060199846-A1 | Certain substituted ureas as modulators of kinase activity | GILEAD CONNECTICUT, INC. | 2006-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060199846-A1 | Certain substituted ureas as modulators of kinase activity | UCK2, CHUK, AXL | MAPT 2782/4885EPHB4 3357/4885S1PR2 3793/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.