Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 8/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5593125 | 1.00 | RAB9A (0.62) | RAB9ANPC1MAPTKDM4EMEN1 | |
| SCHEMBL5593050 | 0.94 | RAB9A (0.55) | RAB9ANPC1MAPTKDM4EMEN1 | |
| SCHEMBL5593046 | 0.94 | RAB9A (0.55) | RAB9ANPC1MAPTKDM4EMEN1 | |
| SCHEMBL5593073 | 0.91 | RAB9A (0.65) | RAB9ANPC1MAPTKDM4EMEN1 | |
| SCHEMBL5593177 | 0.90 | MAPT (0.72) | RAB9ANPC1MAPTKDM4EMEN1 | |
| SCHEMBL5592826 | 0.89 | MAPT (0.65) | RAB9ANPC1MAPTKDM4EMEN1 | |
| SCHEMBL5592821 | 0.89 | MAPT (0.70) | RAB9ANPC1MAPTKDM4EMEN1 | |
| SCHEMBL5593012 | 0.86 | MAPT (0.61) | RAB9ANPC1MAPTKDM4EMEN1 | |
| SCHEMBL5593141 | 0.85 | MEN1 (0.61) | RAB9ANPC1MAPTKDM4EMEN1 | |
| SCHEMBL5593144 | 0.85 | MEN1 (0.61) | RAB9ANPC1MAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007074238-A2 | NOVEL N-ALK-(E)-YLIDENE-N'-PYRIMIDIN-2-YL HYDRAZINE DERIVATIVES AND USE THEREOF AS CYTOPROTECTIVE DRUGS | TROPHOS (FR) | 2007-07-05 | — | — | WO | claimed |
| WO-2007074238-A2 | NOVEL N-ALK-(E)-YLIDENE-N'-PYRIMIDIN-2-YL HYDRAZINE DERIVATIVES AND USE THEREOF AS CYTOPROTECTIVE DRUGS | TROPHOS (FR) | 2007-07-05 | — | — | WO | disclosed |