Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.58 |
| ▸ | MTOR | P42345 | 12/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.46 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5592979 | 0.85 | PIK3CA (0.66) | PIK3CAMTORPIK3CGPIK3CDHTT | |
| SCHEMBL5592988 | 0.82 | PIK3CA (0.61) | PIK3CAMTORPIK3CGPIK3CDHTT | |
| SCHEMBL4937415 | 0.79 | PIK3CA (0.60) | PIK3CAMTORPIK3CGPIK3CDHDAC6 | |
| SCHEMBL5593024 | 0.78 | PIK3CA (0.56) | PIK3CAMTORPIK3CGPIK3CDHTT | |
| SCHEMBL5593037 | 0.78 | PIK3CA (0.66) | PIK3CAMTORPIK3CGPIK3CDHTT | |
| SCHEMBL5592805 | 0.77 | PIK3CA (0.60) | PIK3CAMTORPIK3CGPIK3CDHTT | |
| SCHEMBL5603608 | 0.77 | MTOR (0.60) | PIK3CAMTORPIK3CGPIK3CDHTT | |
| SCHEMBL5593072 | 0.77 | PIK3CA (0.62) | PIK3CAMTORPIK3CGPIK3CDHTT | |
| SCHEMBL4941085 | 0.76 | PIK3CA (0.61) | PIK3CAMTORPIK3CGPIK3CDHTT | |
| SCHEMBL4934392 | 0.76 | PIK3CA (0.66) | PIK3CAMTORPIK3CGPIK3CDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007066099-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-06-14 | — | — | WO | disclosed |