Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21246564 | 0.79 | RECQL (0.58) | TSHRALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL29437185 | 0.79 | RECQL (0.58) | TSHRALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL4551596 | 0.79 | NAMPT (0.54) | TSHRCYP1A2CYP3A4CYP2C9NAMPT | |
| SCHEMBL14473103 | 0.77 | MEN1 (0.46) | TSHRALDH1A1TP53RAB9ANPC1 | |
| SCHEMBL5603996 | 0.76 | NAMPT (0.45) | TSHRTP53LMNACYP1A2CYP3A4 | |
| SCHEMBL4419761 | 0.75 | CYP1A2 (0.49) | TSHRALDH1A1RAB9ANPC1LMNA | |
| SCHEMBL4551597 | 0.75 | MAPK14 (0.60) | TP53NAMPTSMN1; SMN2 | |
| SCHEMBL5603875 | 0.75 | NAMPT (0.41) | TSHRALDH1A1TP53RAB9ANPC1 | |
| SCHEMBL5593016 | 0.74 | TEK (0.53) | TSHRALDH1A1RAB9ANPC1LMNA | |
| SCHEMBL4410223 | 0.74 | MAPK14 (0.47) | TSHRALDH1A1TP53RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |