Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 15/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 15/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5593510 | 0.90 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 | |
| SCHEMBL5593483 | 0.89 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 | |
| SCHEMBL3891686 | 0.83 | SLC6A2 (0.37) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 | |
| SCHEMBL5593356 | 0.81 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 | |
| SCHEMBL4788823 | 0.81 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 | |
| SCHEMBL3563410 | 0.80 | REN (0.40) | SLC6A2SLC6A4SLC6A3HRH1REN | |
| SCHEMBL12991314 | 0.80 | REN (0.40) | SLC6A2SLC6A4SLC6A3HRH1REN | |
| SCHEMBL5593486 | 0.75 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 | |
| SCHEMBL5593463 | 0.75 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 | |
| SCHEMBL5613061 | 0.75 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117560-A2 | PIPERIDINE AND MORPHOLINE RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |