⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6276999 | 0.92 | — | — | |
| SCHEMBL6279566 | 0.89 | ALDH1A1 (0.30) | — | |
| SCHEMBL1652805 | 0.84 | — | — | |
| SCHEMBL9210315 | 0.69 | — | — | |
| SCHEMBL874397 | 0.65 | — | — | |
| SCHEMBL17599071 | 0.65 | — | — | |
| SCHEMBL878490 | 0.65 | — | — | |
| SCHEMBL11683368 | 0.65 | — | — | |
| SCHEMBL2154166 | 0.61 | — | — | |
| SCHEMBL9618584 | 0.59 | ALDH1A1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10632210-B2 | Peptidomimetic compounds and antibody-drug conjugates thereof | GENENTECH, INC. (US) | 2020-04-28 | — | — | US | disclosed |
| US-20190083643-A1 | PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF | GENENTECH, INC. (US) | 2019-03-21 | — | — | US | disclosed |
| US-10124069-B2 | Peptidomimetic compounds and antibody-drug conjugates thereof | GENENTECH, INC. (US) | 2018-11-13 | — | — | US | disclosed |
| US-20160279261-A1 | PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF | GENENTECH, INC. (US) | 2016-09-29 | — | — | US | disclosed |
| EP-1212068-A4 | METHOD OF ENHANCING THE EFFICACY OF ANTI-TUMOR AGENTS | HEALTH RESEARCH INC (US) | 2007-03-14 | — | — | EP | disclosed |
| EP-1212068-A1 | METHOD OF ENHANCING THE EFFICACY OF ANTI-TUMOR AGENTS | HEALTH RESEARCH, INC. (US) | 2002-06-12 | — | — | EP | disclosed |
| WO-2000064455-A1 | METHOD OF ENHANCING THE EFFICACY OF ANTI-TUMOR AGENTS | HEALTH RESEARCH, INC. (US) | 2000-11-02 | — | — | WO | disclosed |
| EP-0642792-B1 | Stabilized solutions of platinum (II) antitumor agents | BRISTOL MYERS SQUIBB CO (US) | 1997-05-02 | — | — | EP | disclosed |
| US-5455270-A | Stabilizing a solution of malonato congener or carboplatin by adding 1,1-cyclobutanedicarboxylic acid or alkali metal salts, pH modifier and a carrier, dissolving, purging and storage in sealed container wherein headspace is filled with air/oxygen | BRISTOL-MYERS SQUIBB CO. (US) | 1995-10-03 | — | — | US | disclosed |
| EP-0642792-A1 | Stabilized solutions of platinum (II) antitumor agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-03-15 | — | — | EP | disclosed |