Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KCNJ6 | P48051 | 12/20 | 0.45 |
| ▸ | KCNJ3 | P48549 | 12/20 | 0.45 |
| ▸ | CRACR2A | Q9BSW2 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KCNJ5 | P48544 | 7/20 | 0.43 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL174681 | 0.78 | SMN1; SMN2 (0.44) | SRCNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL4138174 | 0.73 | NPC1 (0.40) | SRCNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL13234482 | 0.68 | KCNJ6 (0.84) | KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL1011586 | 0.67 | RAB9A (0.88) | NPC1TP53RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1531410 | 0.67 | MAPT (0.47) | NPC1TP53RAB9ASMN1; SMN2KCNJ6 | |
| SCHEMBL13896431 | 0.67 | NPC1 (0.43) | NPC1TP53RAB9ASMN1; SMN2LMNA | |
| SCHEMBL173999 | 0.67 | KDM4E (0.41) | NPC1TP53RAB9ASMN1; SMN2LMNA | |
| SCHEMBL25120811 | 0.65 | ATR (0.45) | NPC1TP53RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL27409551 | 0.65 | GAA (0.42) | SRCNPC1TP53RAB9ASMN1; SMN2 | |
| SCHEMBL23203519 | 0.65 | KCNJ6 (0.65) | NPC1TP53RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202734-B1 | 3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PFIZER ITALIA SRL (IT) | 2007-05-02 | — | — | EP | disclosed |
| EP-1202734-A4 | 3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2004-09-01 | — | — | EP | disclosed |
| CN-1379668-A | 3(5)-ureido-pyrazole derivatives, process for their preparation and their use as antitumor agents | PHARMACIA & UPJOHN SPA (IT) | 2002-11-13 | — | — | CN | disclosed |
| US-6387900-B1 | ANTICANCER AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-05-14 | — | — | US | disclosed |
| EP-1202734-A1 | 3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | Pharmacia Italia S.p.A. (IT) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001012188-A1 | 3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2001-02-22 | — | — | WO | disclosed |