Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 6/20 | 0.46 |
| ▸ | PAK4 | O96013 | 6/20 | 0.46 |
| ▸ | IGF1R | P08069 | 6/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | ROS1 | P08922 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14605900 | 0.86 | PAK1 (0.64) | PAK1PAK4IGF1RDYRK3JAK2 | |
| SCHEMBL4072593 | 0.75 | IGF1R (0.48) | PAK1PAK4IGF1RDYRK3JAK2 | |
| SCHEMBL14605906 | 0.71 | LCK (0.51) | IGF1RLCKRETGSK3BAURKB | |
| SCHEMBL14605959 | 0.71 | LCK (0.51) | IGF1RLCKRETGSK3BAURKB | |
| SCHEMBL4076569 | 0.68 | NTRK1 (0.65) | PAK4IGF1RDYRK3JAK2PRKD3 | |
| SCHEMBL14605893 | 0.66 | PAK1 (0.79) | PAK1PAK4IGF1RDYRK3JAK2 | |
| SCHEMBL14605940 | 0.66 | PAK1 (0.66) | PAK1PAK4IGF1RDYRK3JAK2 | |
| SCHEMBL14605895 | 0.65 | PAK1 (0.65) | PAK1PAK4IGF1RDYRK3JAK2 | |
| SCHEMBL30250067 | 0.64 | PAK1 (0.52) | PAK1PAK4IGF1RRETAURKB | |
| SCHEMBL30250072 | 0.64 | PAK1 (0.54) | PAK1PAK4IGF1RRETACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007023382-A2 | PYRIMIDINE AMINO PYRAZOLE COMPOUNDS, POTENT KINASE INHIBITORS | PFIZER INC. (US) | 2007-03-01 | — | — | WO | disclosed |