Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 5/20 | 0.48 |
| ▸ | PAK4 | O96013 | 4/20 | 0.48 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | ROS1 | P08922 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3339685 | 0.81 | PAK1 (0.66) | IGF1RPAK4PAK1GSK3BDYRK3 | |
| SCHEMBL22054231 | 0.81 | PLK4 (0.60) | PAK4GSK3BAURKBNTRK1SRC | |
| SCHEMBL786513 | 0.79 | ULK1 (0.65) | PAK4PAK1GSK3BAURKBNTRK1 | |
| SCHEMBL29618398 | 0.79 | ULK1 (0.65) | PAK4PAK1GSK3BAURKBNTRK1 | |
| SCHEMBL4070230 | 0.78 | NTRK1 (0.63) | PAK4PAK1GSK3BNTRK1SRC | |
| SCHEMBL4069145 | 0.78 | PAK4 (0.69) | PAK4PAK1GSK3BNTRK1SRC | |
| SCHEMBL22054246 | 0.78 | PLK4 (0.42) | IGF1RPAK4PAK1GSK3BFGFR1 | |
| SCHEMBL4073719 | 0.78 | PAK4 (0.48) | IGF1RPAK4PAK1GSK3BNTRK1 | |
| SCHEMBL4074175 | 0.77 | PAK4 (0.65) | IGF1RPAK4PAK1NTRK1 | |
| SCHEMBL4067519 | 0.77 | IGF1R (0.53) | IGF1RPAK4PAK1GSK3BNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |