Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.59 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.59 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.59 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | GPR183 | P32249 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5598133 | 0.94 | RXRA (0.59) | RXRANR1H2NR1H3ARMAPT | |
| SCHEMBL4908276 | 0.92 | RXRA (0.53) | RXRANR1H2NR1H3MAPTPOLB | |
| SCHEMBL4897271 | 0.91 | RXRA (0.54) | RXRANR1H2NR1H3MAPTPOLB | |
| SCHEMBL2388618 | 0.90 | NR1H2 (0.56) | RXRANR1H2NR1H3ARMAPT | |
| SCHEMBL4907007 | 0.90 | RXRA (0.49) | RXRANR1H2NR1H3MAPTPOLB | |
| SCHEMBL2263662 | 0.90 | RXRA (0.62) | RXRANR1H2NR1H3ARMAPT | |
| SCHEMBL2263683 | 0.90 | NR1H2 (0.65) | RXRANR1H2NR1H3ARMAPT | |
| SCHEMBL2263549 | 0.89 | RXRA (0.62) | RXRANR1H2NR1H3ARMAPT | |
| SCHEMBL12390393 | 0.89 | NR1H2 (0.59) | RXRANR1H2NR1H3ARMAPT | |
| SCHEMBL2263493 | 0.89 | NR1H2 (0.62) | RXRANR1H2NR1H3ARMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773337-A2 | MODULATORS OF NUCLEAR RECEPTORS | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006025979-A9 | MODULATORS OF NUCLEAR RECEPTORS | EXELIXIS INC (US) | 2006-04-20 | — | — | WO | disclosed |
| WO-2006025979-A2 | MODULATORS OF NUCLEAR RECEPTORS | EXELIXIS, INC. (US) | 2006-03-09 | — | — | WO | disclosed |