SCHEMBL5597940

SCHEMBL5597940

N#Cc1c(C(F)(F)F)cc(-c2ccc(-c3cc[c]cc3)s2)n(Cc2ccc(F)cc2F)c1=O

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXRA P19793 4/20 0.74
NR1H2 P55055 4/20 0.74
NR1H3 Q13133 4/20 0.74
MAPK14 Q16539 4/20 0.35
ALDH1A1 P00352 4/20 0.35
KDM4E B2RXH2 4/20 0.35
KMT2A Q03164 2/20 0.35
GAA P10253 1/20 0.35
MAPT P10636 1/20 0.35
HTT P42858 1/20 0.35
POLB P06746 1/20 0.34
PKM P14618 3/20 0.33
HSD17B10 Q99714 2/20 0.33
HPGD P15428 1/20 0.33
GRM2 Q14416 1/20 0.32
TNKS O95271 1/20 0.31
TNKS2 Q9H2K2 1/20 0.31
PKLR P30613 2/20 0.30
P2RX7 Q99572 1/20 0.30
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14214290 0.92 RXRA (0.81) RXRANR1H2NR1H3MAPK14ALDH1A1
SCHEMBL2389277 0.90 RXRA (0.73) RXRANR1H2NR1H3MAPK14ALDH1A1
SCHEMBL2390386 0.90 RXRA (0.73) RXRANR1H2NR1H3MAPK14ALDH1A1
SCHEMBL2386431 0.89 RXRA (0.77) RXRANR1H2NR1H3MAPK14ALDH1A1
SCHEMBL4905026 0.89 RXRA (0.72) RXRANR1H2NR1H3MAPK14ALDH1A1
SCHEMBL2389416 0.88 RXRA (0.73) RXRANR1H2NR1H3MAPK14ALDH1A1
SCHEMBL2388320 0.88 RXRA (0.79) RXRANR1H2NR1H3MAPK14ALDH1A1
SCHEMBL2389942 0.88 RXRA (0.71) RXRANR1H2NR1H3MAPK14ALDH1A1
SCHEMBL2388583 0.88 RXRA (0.71) RXRANR1H2NR1H3MAPK14ALDH1A1
SCHEMBL2391251 0.88 RXRA (0.70) RXRANR1H2NR1H3MAPK14ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1773337-A2 MODULATORS OF NUCLEAR RECEPTORS Exelixis, Inc. (US) 2007-04-18 EP disclosed
WO-2006025979-A9 MODULATORS OF NUCLEAR RECEPTORS EXELIXIS INC (US) 2006-04-20 WO disclosed
WO-2006025979-A2 MODULATORS OF NUCLEAR RECEPTORS EXELIXIS, INC. (US) 2006-03-09 WO disclosed